Program/Scientific Program
Microsymposia

     Biological Macromolecules

 

MS-04	Biophysical Characterization with Single Molecule Approaches
Co-Chairs	Xiao-Dong Su, David Hsiao Chwan-Deng
Day and Time	Wednesday August 6, AM2
Description	This session will present recent methods for analysis of functions of macromolecules that can be applied in conjunction with structural studies, focusing on single-molecule techniques. more
MS-05	The Crystallography of  HIV/AIDS
Co-Chairs	Alex Wlodawer, Wei Yang
Day and Time	Wednesday August 6, AM2
Description	This session will highlight the major advances in understanding HIV replication, infection, and interactions with the human immune system provided by recent structures of HIV and human proteins and their complexes. more
MS-13	Protein-nucleic Acid Interactions
Co-Chairs	Haiwei Song
Day and Time	Wednesday August 6, PM1
Description	This session will focus on complexes between proteins and DNA/RNA. Note that there are separate sessions on "Structural biology of transcriptional and translational control", "Post-translational modification", and "Chromatic and Epigenetics" so those subjects should be avoided. more
MS-16	Structural Immunology: Innate and Cellular Immunity
Co-Chairs	Gregers Rom Andersen, Hao Wu
Day and Time	Wednesday August 6, PM1
Description	This session will present recent structures and associated functional studies of proteins involved in innate and cellular immunity, as well as complexes of these proteins with their targets. more
MS-21	Post-translational Modification
Co-Chairs	Shuya Fukai, Ruiming Xu
Day and Time	Thursday August 7, AM2
Description	This session will present structures and associated functional studies of proteins and complexes involved in post-translational modification and their targets, excluding "Chromatin and epigenetics". more
MS-22	Improving your Crystallography: Best Practices and New Methods
Co-Chairs	Zbigniew Dauter, Maskai Yamamoto
Day and Time	Thursday August 7, AM2
Description	This session will present foundations and recent advances in how to determine macromolecular structures, covering best practices for data collection, data analysis and structure determination. It can include how to choose what crystal to use, how to optimize data collection, how to collect the data, how to monitor and adjust data collection based on radiation damage, as well as new methods and algorithms for structure determination. more
MS-28	Small-angle Scattering of Biological Macromolecules
Co-Chairs	Bente Vestegaard, Zehra Sayers
Day and Time	Thursday August 7, PM1
Description	This session will present recent new methods and recent results for analysis of X-ray and neutron small-angle scattering data on biological macromolecules, including combined studies from crystallography and small-angle scattering. more
MS-29	Enzymes and Macromolecular Machines. Dedicated to Louis Delbaere
Co-Chairs	Michael James, Marie Fraser
Day and Time	Thursday August 7, PM1
Description	This session is dedicated to Louis Delbaere. This session will present recent structures and associated functions of enzyme, particularly focusing on structures of large macromolecular complexes that operate as molecular machines. more
MS-30	Data to Knowledge: How to Get Meaning from Your Result
Co-Chairs	Wladek Minor, John Westbrook
Day and Time	Thursday August 7, PM1
Description	Use of data base information to fully exploit the results of a new structure determination. The session will cover ways to find out if structural features in your structure have been seen before, ways to identify binding sites, active sites, ligands, ions and other features in your structure. more
MS-36	XFEL Macromolecular Crystallography
Co-Chairs	Gwyndaf Evans, Bill Weis
Day and Time	Friday August 8, AM2
Description	Serial crystallography, both nano crystal and more conventional crystal dimensions, is a growing field at the LCLS and SACLA XFEL facilities, with a rapidly expanding user base. This MS will be dedicated to reporting structural biology studies performed at the XFEL sources, potentially including time resolved and novel phasing results in addition to normal 3D structures. more
MS-37	Structural Biology of Bacterial Secretion Systems
Co-Chairs	Konstantin Korotkov, Natalie Strydnaka
Day and Time	Friday August 8, AM2
Description	This session will highlight recent structures of bacterial secretion systems and studies on their interactions with effectors and other proteins translocated through the secretion complexes. more
MS-40	S-SAD and Other Applications of Soft X-rays in MX
Co-Chairs	John Rose, Manfred Weiss
Day and Time	Friday August 8, AM2
Description	This session will present foundations and recent developments in the use of longer-wavelength data collection for macromolecules. It will include the use of Sulfur for SAD phasing and the use of anomalous scatterers with absorption edges at wavelengths significantly longer than 1A. more
MS-45	Molecular Mechanisms of Therapeutics and Resistance
Co-Chairs	Alejandro Buschiazzo, Celia Schiffer
Day and Time	Friday August 8, PM1
Description	This session will include structure-based drug discovery, structural studies of antibiotic resistance, and rational design of vaccines. more
MS-46	XAS of Hydrated Metal Ions and Protein Active Centres in Aqueous Solutions
Co-Chairs	Ingmar Persson, Ritimukta Sarangi
Day and Time	Friday August 8, PM1
Description	To present the real possibilities and limits of XAS analysis (combined with molecular dynamics, for example) in the study of the solvation structure of metals. This includes inorganic and organometallic metal ions, solvation effects on metalloproteins and high pressure interactions. more
MS-51	Challenging Macromolecular Crystals: Twinning, Aperiodicity, and Low Resolution
Co-Chairs	Garib Murshudov, Thomas Schneider
Day and Time	Saturday August 9, AM2
Description	This session will present foundations and recent advances in theory and practice for dealing with challenging crystals, including crystals that are twinned, diffract only to very low resolution, or that are aperiodic. more
MS-53	Disease Related Proteins
Co-Chairs	Menico Rizzi, Sandra Ribeiro
Day and Time	Saturday August 9, AM2
Description	This session will present recent structures and associated functional studies of proteins that are involved in disease, including human, animal and plant diseases. Note that there is another session on "Molecular Mechanisms of therapeutics and resistance" so topics in that area should be avoided. more
MS-54	Biological Macromolecule Structures by Cryo-EM
Co-Chairs	Howard Young, Ingeborg Schmidt-Krey
Day and Time	Saturday August 9, AM2
Description	This session will cover advances in single particle techniques and new structures of large biological macromolecules, which reveal interesting functional insight and push the limits of resolution. more
MS-57	Macromolecular and Soft-matter Aperiodic Crystals (crystallography, growth and self-assembly applications)
Co-Chairs	Thomas Russell, Tomonari Dotera
Day and Time	Saturday August 9, PM1
Description	Studies of soft matter systems (micelles, polymers, colloids, nanoparticles, etc.) that form quasicrystalline and related novell phases. more
MS-61	The Beginnings of Biological Crystallography
Co-Chairs	Eleanor Dodson, Gil Privé
Day and Time	Saturday August 9, PM1
Description	This session will present vivid historical remembrances of the early days of protein crystallography by the early practitioners in a way that connects these early efforts to the most recent accomplishments of structural biology. more
MS-65	Charge Density for Drug Design
Co-Chairs	Cherif Matta, B. Dittrich
Day and Time	Sunday August 10, AM2
Description	Recent charge density studies of molecules of pharmacological interest show the potentiality of such approach for the design of new drugs. The analysis of the topology of the electrostatic potential from theory or experiment enables for the prediction of the formation of chemical bonding or interactions and provides the basis for a rational drug design. more
MS-69	Hot Structures I
Co-Chairs	Daniela Stock, Maria Armenia Carrondo
Day and Time	Sunday August 10, AM2
Description	This session will present recent hot macromolecular structures and associated functional studies.
MS-70	Biological Electron Crystallography
Co-Chairs	Daneng Wang, Werner Kuhlbrandt
Day and Time	Sunday August 10, AM2
Description	This microsymposium will address technical advances in and interesting structures determined by two dimensional electron crystallography. more
MS-77	Techniques and Insights into Macromolecular Crystallization
Co-Chairs	Joseph Ng, Janet Newman
Day and Time	Sunday August 10, PM1
Description	This microsymposium is focused on tools, techniques and technologies that advance the science and success rate of producing X-ray diffraction quality crystals from macromolecules. more
MS-78	Hot Structures II
Co-Chairs	Stephen Burley, Elisabeth Sauer-Eriksson
Day and Time	Sunday August 10, PM1
Description	This session will present recent hot macromolecular structures and associated functional studies.
MS-82	Ultimate Resolution and Neutron Crystallography
Co-Chairs	Svetlana Antonyuk, Mathew Blakeley
Day and Time	Monday August 11, AM2
Description	This session will focus on what can be learned from structures of macromolecules that show locations of hydrogens either from very high-resolution x-ray diffraction or from neutron diffraction. more
MS-85	Enzymes and macromolecular machines - part 2. Dedicated to Louis Delbaere
Co-Chairs	Shaun Lott, Marina Mapelli
Day and Time	Monday August 11, AM2
Description	This session is dedicated to Louis Delbaere. This session will present recent structures and associated functions of enzyme, particularly focusing on structures of large macromolecular complexes that operate as molecular machines. more
MS-93	Structural Biology of Transcriptional and Translational Control
Co-Chairs	Leemor Joshua-Tor, Min Yao
Day and Time	Monday August 11, PM1
Description	This session will include presentations on on structures of proteins and RNAs involved in regulation of transcription and translation. more
MS-100	Beginner's Guide to Validation of Crystallographic Results
Co-Chairs	B. Santarsiero, B. Rupp
Day and Time	Tuesday August 12, AM2
Description	This is intended as a tutorial session on validation: what is validation, what are the key criteria for validation of small-molecule and macromolecular structures, how to interpret a validation result including expected values and how to identify what is an error and what is a an unusual feature, and what to do next if errors or unusual situations are found. A variety of software tools for validation and the tools provided by archives such as the PDB will be described. more
MS-101	Membrane Protein Structure, Function, and Dynamics
Co-Chairs	David Drew, tbc
Day and Time	Tuesday August 12, AM2
Description	This session will present recent structures and associated functional studies of membrane proteins. more
MS-102	Structural Bioinformatics
Co-Chairs	Adam Godzik, Balaji Prakash
Day and Time	Tuesday August 12, AM2
Description	This session will show how bioinformatics can help before you solve your structure. It will show how to choose what part of your molecule to express and crystallize and how to choose mutants to crystallize. It will help you learn whether parts of your molecule are likely to be disordered. It will help identify whether a low-sequence identity homologue of your target protein is really a good structure to solve. more
MS-109	Chromatin and Epigenetics
Co-Chairs	Jinrong Min, Cheryl Arrowsmith
Day and Time	Tuesday August 12, PM1
Description	This session will present structures and associated functional studies on chromatin, chromatin-remodeling systems, post-translational modifications involved in regulation of chromatin and in other epigenetic effects. more
MS-110	Viruses and Viral Proteins
Co-Chairs	M.R.N. Murthy, Nuria Verdaguer
Day and Time	Tuesday August 12, PM1
Description	This session will present recent structures and associated functional studies of viruses and proteins from viruses. more

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