Program/Scientific Program
Microsymposia

      Biological Macromolecules

     

    MS-04 Biophysical Characterization with Single Molecule Approaches
    Description This session will present recent methods for analysis of functions of macromolecules that can be applied in conjunction with structural studies, focusing on single-molecule techniques.
       
    MS-05 The Crystallography of  HIV/AIDS
    Description This session will highlight the major advances in understanding HIV replication, infection, and interactions with the human immune system provided by recent structures of HIV and human proteins and their complexes.
       
    MS-13 Protein-nucleic Acid Interactions
    Description This session will focus on complexes between proteins and DNA/RNA. Note that there are separate sessions on "Structural biology of transcriptional and translational control", "Post-translational modification", and "Chromatic and Epigenetics" so those subjects should be avoided.
       
    MS-16 Structural Immunology: Innate and Cellular Immunity
    Description This session will present recent structures and associated functional studies of proteins involved in innate and cellular immunity, as well as complexes of these proteins with their targets.
       
    MS-21 Post-translational Modification
    Description This session will present structures and associated functional studies of proteins and complexes involved in post-translational modification and their targets. Note that there is a separate session on "Chromatin and epigenetics" so studies in that area should be avoided.
       
    MS-22 Improving your Crystallography: Best Practices and New Methods
    Description This session will present foundations and recent advances in how to determine macromolecular structures, covering best practices for data collection, data analysis and structure determination. It can include how to choose what crystal to use, how to optimize data collection, how to collect the data, how to monitor and adjust data collection based on radiation damage, as well as new methods and algorithms for structure determination.
       
    MS-28 Small-angle Scattering of Biological Macromolecules
    Description This session will present recent new methods and recent results for analysis of X-ray and neutron small-angle scattering data on biological macromolecules, including combined studies from crystallography and small-angle scattering.
    MS-29 Structural Biology of Transcriptional and Translational Control
    Description This session will include presentations on structures of proteins and RNAs involved in regulation of transcription and translation.
       
    MS-30 Data to Knowledge: How to Get Meaning from Your Result
    Description Use of data base information to fully exploit the results of a new structure determination. The session will cover ways to find out if structural features in your structure have been seen before, ways to identify binding sites, active sites, ligands, ions and other features in your structure.
       
    MS-36 XFEL Macromolecular Crystallography
    Description Serial crystallography, both nano crystal and more conventional crystal dimensions, is a growing field at the LCLS and SACLA XFEL facilities, with a rapidly expanding user base. This MS will be dedicated to reporting structural biology studies performed at the XFEL sources, potentially including time resolved and novel phasing results in addition to normal 3D structures.
       
    MS-37 Structural Biology of Bacterial Secretion Systems
    Description This session will highlight recent structures of bacterial secretion systems and studies on their interactions with effectors and other proteins translocated through the secretion complexes.
       
    MS-40 Extended-wavelength Crystallography
    Description This session will present foundations and recent developments in the use of longer-wavelength data collection for macromolecules. It will include the use of Sulfur for SAD phasing and the use of anomalous scatterers with absorption edges at wavelengths significantly longer than 1A.
       
    MS-45 Molecular Mechanisms of Therapeutics and Resistance
    Description This session will include structure-based drug discovery, structural studies of antibiotic resistance, and rational design of vaccines.
       
    MS-46 XAS of Hydrated Metal Ions and Protein Active Centres in Aqueous Solutions
    Description To present the real possibilities and limits of XAS analysis (combined with molecular dynamics, for example) in the study of the solvation structure of metals. This includes inorganic and organometallic metal ions, solvation effects on metalloproteins and high pressure interactions.
       
    MS-51 Challenging Macromolecular Crystals: Twinning, Aperiodicity, and Low Resolution
    Description This session will present foundations and recent advances in theory and practice for dealing with challenging crystals, including crystals that are twinned, diffract only to very low resolution, or that are aperiodic.
       
    MS-53 Disease Related Proteins
    Description This session will present recent structures and associated functional studies of proteins that are involved in disease, including human, animal and plant diseases. Note that there is another session on "Molecular Mechanisms of therapeutics and resistance" so topics in that area should be avoided.
       
    MS-54 Biological Macromolecule Structures by Cryo-EM
    Description This session will cover advances in single particle techniques and new structures of large biological macromolecules, which reveal interesting functional insight and push the limits of resolution.
       
    MS-57 Macromolecular and Soft-matter Aperiodic Crystals (crystallography, growth and self-assembly, applications)
    Description Studies of soft matter systems (micelles, polymers, colloids, nanoparticles, etc.) that form quasicrystalline and related novell phases.
       
    MS-61 The Beginnings of Biological Crystallography
    Description This session will present vivid historical remembrances of the early days of protein crystallography by the early practitioners in a way that connects these early efforts to the most recent accomplishments of structural biology.
       
    MS-65 Charge Density for Drug Design
    Description Recent charge density studies of molecules of pharmacological interest show the potentiality of such approach for the design of new drugs. The analysis of the topology of the electrostatic potential from theory or experiment enables for the prediction of the formation of chemical bonding or interactions and provides the basis for a rational drug design.
       
    MS-69 Hot Structures I
    Description This session will present recent hot structures and associated functional studies.
       
    MS-70 Biological Electron Crystallography
    Description This microsymposium will address technical advances in and interesting structures determined by two dimensional electron crystallography.
       
    MS-77 Techniques and Insights into Macromolecular Crystallization
    Description This microsymposium is focused on tools, techniques and technologies that advance the science and success rate of producing X-ray diffraction quality crystals from macromolecules.
       
    MS-78 Hot Structures II
    Description This session will present recent hot structures and associated functional studies.
       
    MS-82 Ultimate Resolution and Neutron Crystallography
    Description This session will focus on what can be learned from structures of macromolecules that show locations of hydrogens either from very high-resolution x-ray diffraction or from neutron diffraction.
       
    MS-85 G Protein-coupled Receptors
    Description This session will present recent structures and associated functional studies on G protein-coupled receptors.
       
    MS-93 Enzymes and Macromolecular Machines. Dedicated to Louis Delbaere
    Description This session is dedicated to Louis Delbaere. This session will present recent structures and associated functions of enzyme, particularly focusing on structures of large macromolecular complexes that operate as molecular machines.
       
    MS-100 Beginner's Guide to Validation of Crystallographic Results
    Description This is intended as a tutorial session on validation: what is validation, what are the key criteria for validation of small-molecule and macromolecular structures, how to interpret a validation result including expected values and how to identify what is an error and what is a an unusual feature, and what to do next if errors or unusual situations are found. A variety of software tools for validation and the tools provided by archives such as the PDB will be described.
       
    MS-101 Membrane Protein Structure, Function, and Dynamics
    Description This session will present recent structures and associated functional studies of membrane proteins.
       
    MS-102 Structural Bioinformatics
    Description This session will show how bioinformatics can help before you solve your structure. It will show how to choose what part of your molecule to express and crystallize and how to choose mutants to crystallize. It will help you learn whether parts of your molecule are likely to be disordered. It will help identify whether a low-sequence identity homologue of your target protein is really a good structure to solve.
       
    MS-109 Chromatin and Epigenetics
    Description This session will present structures and associated functional studies on chromatin, chromatin-remodeling systems, post-translational modifications involved in regulation of chromatin and in other epigenetic effects.
       
    MS-110 Viruses and Viral Proteins
    Description This session will present recent structures and associated functional studies of viruses and proteins from viruses.